Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 6/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2278401 | 0.90 | SYK (0.41) | MAP4K1SYKCYP2D6KCNH2CYP2C9 | |
| SCHEMBL2344505 | 0.87 | MAP4K1 (0.36) | MAP4K1SYKCYP2D6CYP2C9 | |
| SCHEMBL2273339 | 0.82 | JAK3 (0.43) | MAP4K1SYKCYP2D6KCNH2CYP2C9 | |
| SCHEMBL3063499 | 0.81 | MAP4K1 (0.40) | MAP4K1SYKCYP2D6KCNH2NTRK1 | |
| SCHEMBL2278409 | 0.78 | SYK (0.38) | MAP4K1SYKCYP2D6KCNH2NTRK1 | |
| SCHEMBL2348276 | 0.77 | SYK (0.38) | MAP4K1SYKCYP2D6KCNH2 | |
| SCHEMBL2274314 | 0.75 | SYK (0.41) | SYKCYP2D6KCNH2CYP2C9 | |
| SCHEMBL2344717 | 0.74 | SYK (0.37) | MAP4K1SYKCYP2D6KCNH2CYP2C9 | |
| SCHEMBL2350193 | 0.72 | SYK (0.38) | MAP4K1SYKCYP2C9 | |
| SCHEMBL2351523 | 0.72 | SYK (0.54) | SYKCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | claimed |