Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22784199 | 0.80 | NPC1 (0.32) | CYP1A2 | |
| SCHEMBL10733702 | 0.71 | GSK3A (0.36) | CYP1A2TSHRLMNAALDH1A1L3MBTL1 | |
| SCHEMBL4702420 | 0.69 | CYP1A2 (0.45) | CYP1A2TSHRLMNAPOLBALDH1A1 | |
| SCHEMBL22784200 | 0.69 | HCAR2 (0.38) | LMNAALDH1A1RAB9AOPRM1SLC22A1 | |
| SCHEMBL22777434 | 0.67 | TSHR (0.42) | CYP1A2TSHRLMNAPOLBALDH1A1 | |
| SCHEMBL1863674 | 0.67 | CYP1A2 (0.47) | CYP1A2TSHRLMNAPOLBALDH1A1 | |
| SCHEMBL28078421 | 0.66 | CYP1A2 (0.45) | CYP1A2TSHRLMNAPOLBALDH1A1 | |
| SCHEMBL23484497 | 0.64 | CYP1A2 (0.44) | CYP1A2TSHRLMNAPOLBALDH1A1 | |
| SCHEMBL5109822 | 0.64 | CYP1A2 (0.44) | CYP1A2TSHRLMNAPOLBALDH1A1 | |
| SCHEMBL2352990 | 0.64 | ALDH1A1 (0.45) | CYP1A2TSHRLMNAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252222-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2020-12-17 | — | — | WO | disclosed |