Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.50 |
| ▸ | LIPE | Q05469 | 2/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5938227 | 1.00 | NR1H2 (0.50) | NR1H2LIPEDDB1CRBNUSP30 | |
| SCHEMBL43652 | 1.00 | NR1H2 (0.50) | NR1H2LIPEDDB1CRBNUSP30 | |
| SCHEMBL43653 | 1.00 | NR1H2 (0.50) | NR1H2LIPEDDB1CRBNUSP30 | |
| SCHEMBL29560774 | 1.00 | NR1H2 (0.50) | NR1H2LIPEDDB1CRBNUSP30 | |
| SCHEMBL29965040 | 0.93 | LIPE (0.45) | NR1H2LIPEDDB1CRBNUSP30 | |
| SCHEMBL14239659 | 0.91 | NR1H2 (0.48) | NR1H2LIPEDDB1CRBNUSP30 | |
| SCHEMBL1692080 | 0.91 | NR1H2 (0.48) | NR1H2LIPEDDB1CRBNUSP30 | |
| SCHEMBL5940329 | 0.86 | NR1H2 (0.54) | NR1H2LIPEDDB1CRBNUSP30 | |
| SCHEMBL5938643 | 0.86 | NR1H2 (0.54) | NR1H2LIPEDDB1CRBNUSP30 | |
| SCHEMBL14239632 | 0.84 | NR1H2 (0.52) | NR1H2LIPEDDB1CRBNUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252222-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2020-12-17 | — | — | WO | disclosed |