Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2273712 | 0.84 | HTR6 (0.45) | HTR6BCHEJAK2JAK1TP53 | |
| SCHEMBL2277491 | 0.83 | JAK2 (0.46) | HTR6JAK2JAK1TYK2JAK3 | |
| SCHEMBL2278876 | 0.83 | JAK1 (0.40) | HTR6JAK2JAK1TYK2JAK3 | |
| SCHEMBL2277274 | 0.83 | HTR6 (0.48) | HTR6BCHEJAK2JAK1TYK2 | |
| SCHEMBL2276678 | 0.82 | HTR6 (0.48) | HTR6BCHE | |
| SCHEMBL2224307 | 0.82 | HTR6 (0.48) | HTR6BCHEJAK2JAK1TYK2 | |
| SCHEMBL2276483 | 0.82 | HTR6 (0.48) | HTR6BCHE | |
| SCHEMBL23610242 | 0.81 | JAK2 (0.51) | HTR6JAK2JAK1TYK2JAK3 | |
| SCHEMBL21490878 | 0.81 | JAK2 (0.51) | HTR6JAK2JAK1TYK2JAK3 | |
| SCHEMBL2279585 | 0.81 | JAK1 (0.63) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |