Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.31 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.31 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22787056 | 1.00 | COMT (0.34) | COMTHTR2AKCNH2KDM2BKDM4C | |
| SCHEMBL27269805 | 0.92 | COMT (0.34) | COMTKCNH2KDM2BKDM4CSCN9A | |
| SCHEMBL21786435 | 0.92 | COMT (0.37) | COMTHTR2AKCNH2KDM2BKDM4C | |
| SCHEMBL27364374 | 0.89 | RARA (0.37) | COMTKCNH2KDM2BKDM4CSTIM1 | |
| SCHEMBL27269709 | 0.88 | HTR2A (0.34) | COMTHTR2AKCNH2KDM2BKDM4C | |
| SCHEMBL27349291 | 0.88 | PTGDR2 (0.34) | COMTSPHK2S1PR1 | |
| SCHEMBL22791165 | 0.86 | COMT (0.37) | COMTHTR2AKCNH2STIM1ORAI1 | |
| SCHEMBL22791180 | 0.84 | COMT (0.36) | COMTKCNH2STIM1ORAI1SCN9A | |
| SCHEMBL22790953 | 0.83 | PPARD (0.34) | COMTSTIM1ORAI1SCN9A | |
| SCHEMBL27365158 | 0.82 | COMT (0.32) | COMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240207413-A1 | PROTEOLYSIS-TARGETING CHIMERIC MOLECULES (PROTACS) THAT INDUCE DEGRADATION OF C-MYC PROTEIN | NORTHWESTERN UNIVERSITY | 2024-06-27 | — | — | US | disclosed |
| US-20200390894-A1 | PROTEOLYSIS-TARGETING CHIMERIC MOLECULES (PROTACS) THAT INDUCE DEGRADATION OF C-MYC PROTEIN | NORTHWESTERN UNIVERSITY (US) | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200390894-A1 | PROTEOLYSIS-TARGETING CHIMERIC MOLECULES (PROTACS) THAT INDUCE DEGRADATION OF C-MYC PROTEIN | MYCBP, MYC, MYCBP2 | COMT 2382/4885HTR2A 3806/4885KCNH2 4377/4885 |
| US-20240207413-A1 | PROTEOLYSIS-TARGETING CHIMERIC MOLECULES (PROTACS) THAT INDUCE DEGRADATION OF C-MYC PROTEIN | MYCBP, MYC, MYCBP2 | COMT 2382/4885HTR2A 3806/4885KCNH2 4377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.