Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.47 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22791260 | 0.96 | TMPRSS4 (0.51) | TMPRSS4BRAFMAPTLMNAGAA | |
| SCHEMBL21786604 | 0.88 | ORAI1 (0.60) | TMPRSS4MAPTLMNARAB9ASTIM1 | |
| SCHEMBL22825553 | 0.84 | MAPT (0.43) | TMPRSS4BRAFMAPTLMNAGAA | |
| SCHEMBL22791396 | 0.83 | TMPRSS4 (0.49) | TMPRSS4BRAFMAPTLMNAGAA | |
| SCHEMBL2592332 | 0.82 | STIM1 (0.49) | TMPRSS4MAPTSTIM1ORAI1GRM4 | |
| SCHEMBL22790724 | 0.82 | RAB9A (0.44) | TMPRSS4BRAFLMNARAB9ASTIM1 | |
| SCHEMBL22791063 | 0.80 | RAB9A (0.44) | LMNARAB9ASTIM1ORAI1HDAC3 | |
| SCHEMBL22791160 | 0.79 | TMPRSS4 (0.52) | TMPRSS4BRAFMAPTLMNAGAA | |
| SCHEMBL2586511 | 0.78 | ORAI1 (0.58) | MAPTLMNARAB9ASTIM1ORAI1 | |
| SCHEMBL2592032 | 0.78 | ORAI1 (0.55) | MAPTLMNARAB9ASTIM1ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240207413-A1 | PROTEOLYSIS-TARGETING CHIMERIC MOLECULES (PROTACS) THAT INDUCE DEGRADATION OF C-MYC PROTEIN | NORTHWESTERN UNIVERSITY | 2024-06-27 | — | — | US | disclosed |
| US-20200390894-A1 | PROTEOLYSIS-TARGETING CHIMERIC MOLECULES (PROTACS) THAT INDUCE DEGRADATION OF C-MYC PROTEIN | NORTHWESTERN UNIVERSITY (US) | 2020-12-17 | — | — | US | disclosed |
| US-20200392116-A1 | SUBSTITUTED HETEROCYCLES AS c-MYC TARGETING AGENTS | NORTHWESTERN UNIVERSITY (US) | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200390894-A1 | PROTEOLYSIS-TARGETING CHIMERIC MOLECULES (PROTACS) THAT INDUCE DEGRADATION OF C-MYC PROTEIN | MYCBP, MYC, MYCBP2 | TMPRSS4 1322/4885BRAF 921/4885MAPT 2474/4885 |
| US-20200392116-A1 | SUBSTITUTED HETEROCYCLES AS c-MYC TARGETING AGENTS | MYC, MYCBP, MYCBP2 | TMPRSS4 1746/4885BRAF 30/4885MAPT 3689/4885 |
| US-20240207413-A1 | PROTEOLYSIS-TARGETING CHIMERIC MOLECULES (PROTACS) THAT INDUCE DEGRADATION OF C-MYC PROTEIN | MYCBP, MYC, MYCBP2 | TMPRSS4 1322/4885BRAF 921/4885MAPT 2474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.