Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | KCNQ4 | P56696 | 3/20 | 0.34 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29494793 | 1.00 | AAK1 (0.39) | AAK1PRMT5WDR77CA12CA1 | |
| SCHEMBL22777316 | 0.83 | HIF1A (0.35) | CA1CA9HIF1A | |
| SCHEMBL29178771 | 0.81 | CA12 (0.40) | AAK1PRMT5WDR77CA12CA1 | |
| SCHEMBL8219454 | 0.81 | AAK1 (0.39) | AAK1PRMT5WDR77CA12CA1 | |
| SCHEMBL12072846 | 0.79 | AAK1 (0.40) | AAK1PRMT5WDR77CA12CA1 | |
| SCHEMBL1675741 | 0.78 | AAK1 (0.42) | AAK1PRMT5WDR77CA12CA1 | |
| SCHEMBL8221807 | 0.78 | AAK1 (0.41) | AAK1PRMT5WDR77USP30KCNQ4 | |
| SCHEMBL31534338 | 0.77 | AAK1 (0.36) | AAK1PRMT5WDR77KCNQ4KCNQ5 | |
| SCHEMBL23564449 | 0.77 | AAK1 (0.41) | AAK1PRMT5WDR77KCNQ4KCNQ5 | |
| SCHEMBL20396303 | 0.77 | AAK1 (0.44) | AAK1PRMT5WDR77USP30KCNQ4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114302877-A | Quinazolinyl compounds and methods of use | 基因泰克公司 | 2022-04-08 | — | — | CN | disclosed |
| WO-2020252165-A1 | QUINAZOLINYL COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2020-12-17 | — | — | WO | disclosed |