Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.61 |
| ▸ | MAP3K7 | O43318 | 8/20 | 0.61 |
| ▸ | MAP4K2 | Q12851 | 8/20 | 0.61 |
| ▸ | MAP3K20 | Q9NYL2 | 7/20 | 0.61 |
| ▸ | CSK | P41240 | 4/20 | 0.61 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.61 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 3/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.61 |
| ▸ | RAF1 | P04049 | 2/20 | 0.61 |
| ▸ | LYN | P07948 | 2/20 | 0.61 |
| ▸ | SRC | P12931 | 2/20 | 0.61 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.61 |
| ▸ | ABL2 | P42684 | 2/20 | 0.61 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.61 |
| ▸ | FES | P07332 | 1/20 | 0.60 |
| ▸ | FER | P16591 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2282784 | 1.00 | MAPK14 (0.61) | MAPK14MAP3K7MAP4K2MAP3K20CSK | |
| SCHEMBL2284124 | 0.88 | MAPK14 (0.75) | MAPK14MAP3K7MAP4K2MAP3K20CSK | |
| SCHEMBL2282782 | 0.86 | DDR1 (0.78) | MAPK14MAP3K7MAP4K2MAP3K20CSK | |
| SCHEMBL2283236 | 0.85 | BRAF (0.64) | MAPK14MAP3K7MAP4K2MAP3K20CSK | |
| SCHEMBL17208708 | 0.83 | MAPK14 (0.65) | MAPK14MAP3K7MAP4K2MAP3K20CSK | |
| SCHEMBL2280492 | 0.82 | DDR1 (0.46) | MAPK14MAP3K7MAP4K2MAP3K20CSK | |
| SCHEMBL17208710 | 0.81 | MAP3K20 (0.64) | MAPK14MAP3K7MAP4K2MAP3K20CSK | |
| SCHEMBL2280189 | 0.80 | HCK (0.60) | MAPK14MAP3K7MAP4K2MAP3K20FES | |
| SCHEMBL17208712 | 0.80 | BRAF (0.67) | MAPK14MAP3K7MAP4K2MAP3K20CSK | |
| SCHEMBL2289046 | 0.79 | BRAF (0.72) | ABL1FLT3EGFRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011090738-A2 | TYPE II RAF KINASE INHIBITORS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2011-07-28 | — | — | WO | disclosed |