Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.65 |
| ▸ | MAP3K20 | Q9NYL2 | 6/20 | 0.65 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.64 |
| ▸ | MAP3K7 | O43318 | 7/20 | 0.59 |
| ▸ | MAP4K2 | Q12851 | 7/20 | 0.59 |
| ▸ | CSK | P41240 | 4/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | RAF1 | P04049 | 2/20 | 0.56 |
| ▸ | LYN | P07948 | 2/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.56 |
| ▸ | ABL2 | P42684 | 2/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.56 |
| ▸ | FES | P07332 | 1/20 | 0.55 |
| ▸ | FER | P16591 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | BRAF | P15056 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17208710 | 0.95 | MAP3K20 (0.64) | MAPK14MAP3K20DDR1MAP3K7MAP4K2 | |
| SCHEMBL2282782 | 0.91 | DDR1 (0.78) | MAPK14MAP3K20DDR1MAP3K7MAP4K2 | |
| SCHEMBL17208651 | 0.88 | MAPK14 (0.69) | MAPK14MAP3K20DDR1MAP3K7MAP4K2 | |
| SCHEMBL17208615 | 0.87 | DDR1 (0.82) | MAPK14MAP3K20DDR1MAP3K7MAP4K2 | |
| SCHEMBL17208712 | 0.84 | BRAF (0.67) | MAPK14MAP3K20DDR1MAP3K7MAP4K2 | |
| SCHEMBL2282784 | 0.83 | MAPK14 (0.61) | MAPK14MAP3K20DDR1MAP3K7MAP4K2 | |
| SCHEMBL2278939 | 0.83 | MAPK14 (0.61) | MAPK14MAP3K20DDR1MAP3K7MAP4K2 | |
| SCHEMBL2278943 | 0.82 | DDR1 (0.65) | MAPK14MAP3K20DDR1MAP3K7MAP4K2 | |
| SCHEMBL17208613 | 0.82 | MAP3K20 (0.81) | MAPK14MAP3K20DDR1MAP3K7MAP4K2 | |
| SCHEMBL17208707 | 0.80 | MAPT (0.47) | DDR1EGFRBRAFKMT2ARET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9180127-B2 | Type II Raf kinase inhibitors | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-11-10 | — | — | US | disclosed |
| US-9180127-B2 | Type II Raf kinase inhibitors | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-11-10 | — | — | US | disclosed |
| EP-2937345-A2 | Type II raf kinase inhibitors | Dana-Farber Cancer Institute, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |