Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL1668636 | 1.00 | HRH4 (0.42) | — | |
| Histamine SCHEMBL5447892 | 1.00 | — | — | |
| Histamine SCHEMBL27340939 | 1.00 | — | — | |
| Histamine SCHEMBL7444650 | 1.00 | HRH4 (0.42) | — | |
| Histamine SCHEMBL289072 | 1.00 | HRH4 (0.42) | — | |
| Histamine SCHEMBL584026 | 0.98 | TDP1 (0.44) | — | |
| Histamine SCHEMBL991718 | 0.98 | — | — | |
| Histamine SCHEMBL931130 | 0.98 | — | — | |
| Histamine SCHEMBL21806473 | 0.98 | — | — | |
| Histamine SCHEMBL6453806 | 0.98 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 187420 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260146967-A1 | DEVICE AND SENSOR FOR DETECTION OF AN ANALYTE | REMINDED, INC. (US) | 2026-05-28 | — | — | US | claimed |
| US-20260144822-A1 | Treatment of Burn Patients with Hypoxic Blood | HEMANEXT INC. (US) | 2026-05-28 | — | — | US | claimed |
| EP-4747627-A1 | METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS | Matterworks Inc (US) | 2026-05-27 | — | — | EP | claimed |
| CN-122094693-A | Treatment of chronic idiopathic urticaria by administration of (R) -2- [3- [ 4-amino-3- (2-fluoro-4-phenoxy-phenyl) pyrazolo [3,4-D ] pyrimidin-1-yl ] piperidine-1-carbonyl ] -4-methyl-4- [4- (oxetan-3-yl) piperazin-1-yl ] pent-2-enenitrile | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075382-A | Preparation method and application of purslane exosome with anti-sensitization effect | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075525-A | Application of ginseng polysaccharide in preparing medicine for improving allergy caused by gluten intake | — | 2026-05-26 | — | — | CN | claimed |
| CN-122090957-A | Probiotic ratio prediction method and system based on multi-source data characteristics | — | 2026-05-26 | — | — | CN | claimed |
| CN-115985521-B | Qingkailing injection anaphylactic reaction detection model | GUANGZHOU BAIYUN SHAN MING XING PHARMACEUTICAL Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| US-12636476-B2 | Method of implantation of cell aggregates and tissue fragments | NEURONANO AB (SE) | 2026-05-26 | — | — | US | claimed |
| CN-122080927-A | Biogenic amine visual detection method based on carbon dot/quantum dot ratio fluorescent probe and application | — | 2026-05-26 | — | — | CN | claimed |
| US-4002479-A | ORGANIC SILVER SALT, SILVER HALIDE, AND A REDUCING AGENT | FUJI PHOTO FILM CO., LTD. (JA) | 1977-01-11 | — | — | US | claimed |
| US-4000302-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-12-28 | — | — | US | claimed |
| US-3995036-A | Methods of treating a mammal afflicted with excessive histamine with dialkylaminoalkyl ethers of 2-alkoxy-3,5-dihalobenzene and salts thereof | SOCIETE D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE-DE-FRANCE (FR) | 1976-11-30 | — | — | US | claimed |
| US-3984368-A | Ethylene-difunctional olefin-alkyl vinyl terpolymer emulsions | COSDEN TECHNOLOGY, INC. (US) | 1976-10-05 | — | — | US | claimed |
| US-3984401-A | Process for producing lactol-type cephalosporins | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1976-10-05 | — | — | US | claimed |
| US-3973038-A | N-SUBSTITUTED PHENYL 2-HYDROXY BENZAMIDES | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JA) | 1976-08-03 | — | — | US | claimed |
| US-3965257-A | DIPHENYL-4-PIPERIDYL-METHANES | RICHARDSON-MERRELL INC. (US) | 1976-06-22 | — | — | US | claimed |
| US-3963495-A | Image-receiving element for silver salt diffusion transfer with layer of monoacrylates or monomethacrylates of polyhydric alcohols | FUJI PHOTO FILM CO., LTD. (JA) | 1976-06-15 | — | — | US | claimed |
| US-3944526-A | N-cyanosulfonamide resins and intermediates therefor and products thereof | CIBA-GEIGY CORPORATION (US) | 1976-03-16 | — | — | US | claimed |
| US-3935082-A | Process for making lead electrode | RHEINISCH-WESTFALISCHES ELEKTRIZITATSWERK AG (DT) | 1976-01-27 | — | — | US | claimed |