Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 12/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1096257 | 0.92 | POLB (0.67) | POLBNR1H4ALDH1A1GAAMAPT | |
| SCHEMBL22790236 | 0.88 | POLB (0.58) | POLBNR1H4ALDH1A1GAAMAPT | |
| SCHEMBL28596013 | 0.81 | POLB (0.49) | POLBNR1H4ALDH1A1GAAMAPT | |
| SCHEMBL22570976 | 0.80 | NR1H4 (0.49) | POLBNR1H4ALDH1A1GAA | |
| SCHEMBL22397165 | 0.80 | POLB (0.50) | POLBNR1H4ALDH1A1GAA | |
| SCHEMBL2002892 | 0.80 | NR1H4 (0.54) | POLBNR1H4ALDH1A1MAPT | |
| SCHEMBL22790391 | 0.80 | NR1H4 (0.51) | NR1H4 | |
| SCHEMBL22790209 | 0.80 | NR1H4 (0.45) | NR1H4 | |
| SCHEMBL22772582 | 0.78 | NR1H4 (0.50) | POLBNR1H4ALDH1A1GAA | |
| SCHEMBL19899889 | 0.78 | NR1H4 (0.51) | POLBNR1H4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020249064-A1 | COMPOUNDS FOR MODULATING FXR | NANJING RUIJIE PHARMA CO., LTD. (CN) | 2020-12-17 | — | — | WO | disclosed |