Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SHBG | P04278 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22416728 | 1.00 | KDM4E (0.48) | KDM4EKCNH2ALDH1A1HSD17B10SHBG | |
| SCHEMBL1037554 | 1.00 | KDM4E (0.48) | KDM4EKCNH2ALDH1A1HSD17B10SHBG | |
| SCHEMBL24728 | 1.00 | — | — | |
| SCHEMBL11573949 | 1.00 | KDM4E (0.48) | KDM4EKCNH2ALDH1A1HSD17B10SHBG | |
| SCHEMBL22316957 | 1.00 | KDM4E (0.48) | KDM4EKCNH2ALDH1A1HSD17B10SHBG | |
| SCHEMBL1485686 | 1.00 | KDM4E (0.48) | KDM4EKCNH2ALDH1A1HSD17B10SHBG | |
| SCHEMBL17041905 | 0.97 | KDM4E (0.46) | KDM4EKCNH2ALDH1A1HSD17B10SHBG | |
| Fluoride SCHEMBL9620604 | 0.97 | KDM4E (0.46) | KDM4EKCNH2ALDH1A1HSD17B10SHBG | |
| Ammonia Solution, Strong SCHEMBL28857856 | 0.97 | KDM4E (0.46) | KDM4EKCNH2ALDH1A1HSD17B10SHBG | |
| Bromide SCHEMBL28155616 | 0.97 | KDM4E (0.46) | KDM4EKCNH2ALDH1A1HSD17B10SHBG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251972-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |
| WO-2020251971-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |