SCHEMBL22791815

SCHEMBL22791815

CN1CCN(Cc2cc(N)ccc2O)CC1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 3/20 0.73
NR1H2 P55055 1/20 0.58
LMNA P02545 3/20 0.56
BACE1 P56817 1/20 0.50
PRKCI P41743 1/20 0.47
MPO P05164 1/20 0.47
ALDH1A1 P00352 3/20 0.47
KDM4E B2RXH2 2/20 0.47
POLB P06746 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
HPGD P15428 1/20 0.47
ALOX15 P16050 1/20 0.47
CACNA1B Q00975 1/20 0.47
TSHR P16473 3/20 0.46
GFER P55789 1/20 0.46
MAPT P10636 1/20 0.45
ATM Q13315 1/20 0.44
ERAP1 Q9NZ08 1/20 0.44
NR1D1 P20393 1/20 0.44
NR1D2 Q14995 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL126246 0.92 ACHE (0.86) ACHENR1H2LMNABACE1PRKCI
SCHEMBL29565193 0.92 ACHE (0.86) ACHENR1H2LMNABACE1PRKCI
Hydrochloric Acid SCHEMBL5694431 0.90 ACHE (0.87) ACHENR1H2LMNABACE1PRKCI
SCHEMBL28837434 0.85 ACHE (1.00) ACHEBACE1PRKCIMPOALDH1A1
SCHEMBL27604609 0.84 ACHE (0.73) ACHELMNABACE1PRKCIMPO
SCHEMBL22791806 0.84 ACHE (0.64) ACHENR1H2LMNABACE1PRKCI
SCHEMBL6273608 0.83 NR1H2 (0.61) ACHENR1H2LMNAMPOALDH1A1
Hydrochloric Acid SCHEMBL6268461 0.82 NR1H2 (0.60) ACHENR1H2LMNAMPOALDH1A1
SCHEMBL3396724 0.82 NR1H2 (0.60) ACHENR1H2LMNAALDH1A1KDM4E
SCHEMBL32665328 0.81 CHKA (0.55) ACHENR1H2LMNABACE1MPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020248075-A9 TARGETING DNA REPAIR IN TUMOR CELLS VIA INHIBITION OF ERCC1-XPF THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2021-10-21 WO disclosed
WO-2020248075-A1 TARGETING DNA REPAIR IN TUMOR CELLS VIA INHIBITION OF ERCC1-XPF THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2020-12-17 WO disclosed