Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | KIF11 | P52732 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2364746 | 0.85 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAHTTALDH1A1GAA | |
| SCHEMBL15963707 | 0.79 | ALDH1A1 (0.71) | SMN1; SMN2LMNAHTTALDH1A1GAA | |
| SCHEMBL13898348 | 0.78 | AR (0.64) | SMN1; SMN2LMNAHTTALDH1A1CA12 | |
| SCHEMBL2371771 | 0.77 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAHTTKIF11ALDH1A1 | |
| SCHEMBL1031792 | 0.77 | PTPRZ1 (0.45) | SMN1; SMN2LMNAALDH1A1CA12CA1 | |
| SCHEMBL18118512 | 0.77 | CA12 (0.59) | HTTKIF11ALDH1A1CA12CA1 | |
| SCHEMBL27170892 | 0.77 | SMN1; SMN2 (0.73) | SMN1; SMN2LMNAHTTKIF11ALDH1A1 | |
| SCHEMBL2494494 | 0.76 | ALDH1A1 (0.45) | SMN1; SMN2LMNAHTTALDH1A1GAA | |
| SCHEMBL6911956 | 0.76 | TNNI3K (0.55) | KIF11ALDH1A1CA1CA2MEN1 | |
| SCHEMBL6846126 | 0.76 | TSHR (0.64) | SMN1; SMN2LMNAHTTALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523559-A1 | COMPOUNDS AND METHODS | GlaxoSmithKline LLC (US) | 2012-11-21 | — | — | EP | claimed |
| WO-2011088027-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-07-21 | — | — | WO | claimed |
| EP-2523559-A1 | COMPOUNDS AND METHODS | GlaxoSmithKline LLC (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088027-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-07-21 | — | — | WO | disclosed |