Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 3/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826503 | 0.86 | KDM4E (0.52) | KDM4EGAAALDH1A1MAPTNPBWR1 | |
| SCHEMBL13067188 | 0.86 | KDM4E (0.52) | KDM4EGAAALDH1A1MAPTNPBWR1 | |
| SCHEMBL22792261 | 0.86 | KDM4E (0.52) | KDM4EGAAALDH1A1MAPTNPBWR1 | |
| SCHEMBL844082 | 0.86 | GAA (0.52) | KDM4EGAAALDH1A1MAPTHRH3 | |
| SCHEMBL844470 | 0.86 | GAA (0.52) | KDM4EGAAALDH1A1MAPTNPBWR1 | |
| SCHEMBL28765758 | 0.83 | KDM4E (0.50) | KDM4EGAAALDH1A1MAPTNPBWR1 | |
| SCHEMBL1666554 | 0.80 | ALDH1A1 (0.61) | KDM4EALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14376090 | 0.80 | KDM4E (0.56) | KDM4EGAAALDH1A1HRH3MEN1 | |
| SCHEMBL25018511 | 0.79 | ALDH1A1 (0.54) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL21161033 | 0.79 | KMT2A (0.67) | KDM4EGAAALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252229-A2 | INHIBITORS OF SARM1 | DISARM THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |