Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.77 |
| ▸ | MEN1 | O00255 | 9/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.77 |
| ▸ | HPGD | P15428 | 6/20 | 0.77 |
| ▸ | MAPT | P10636 | 6/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.77 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.77 |
| ▸ | RECQL | P46063 | 5/20 | 0.77 |
| ▸ | BLM | P54132 | 5/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.77 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.77 |
| ▸ | TP53 | P04637 | 4/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.77 |
| ▸ | PMP22 | Q01453 | 4/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrphostin Ag 490 SCHEMBL2279210 | 0.88 | EGFR (1.00) | EGFRMEN1KMT2AALDH1A1HPGD | |
| Tyrphostin Ag 490 SCHEMBL93683 | 0.88 | EGFR (1.00) | EGFRMEN1KMT2AALDH1A1HPGD | |
| Tyrphostin Ag 490 SCHEMBL29379893 | 0.88 | EGFR (1.00) | EGFRMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL28514886 | 0.88 | ALDH1A1 (0.54) | EGFRMEN1KMT2AALDH1A1HPGD | |
| Tyrphostin Ag 490 SCHEMBL93682 | 0.88 | EGFR (1.00) | EGFRMEN1KMT2AALDH1A1HPGD | |
| Tyrphostin Ag 490 SCHEMBL17743575 | 0.88 | EGFR (1.00) | EGFRMEN1KMT2AALDH1A1HPGD | |
| Tyrphostin Ag 490 SCHEMBL29351367 | 0.88 | EGFR (1.00) | EGFRMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7378564 | 0.77 | EGFR (1.00) | EGFRMEN1KMT2AALDH1A1HPGD | |
| Ls-104 SCHEMBL3956490 | 0.75 | MAOB (1.00) | EGFRMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL645291 | 0.75 | EGFR (1.00) | EGFRMEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180460-B2 | Amino pyrimidine derivatives | NOVARTIS AG (CH) | 2021-11-23 | — | — | US | disclosed |
| US-8791100-B2 | Aryl benzylamine compounds | NOVARTIS AG (CH) | 2014-07-29 | — | — | US | disclosed |
| US-20130072396-A1 | Transplant Rejection Markers | NOVARTIS AG (CH) | 2013-03-21 | — | — | US | disclosed |
| US-20110190258-A1 | ARYL BENZYLAMINE COMPOUNDS | NOVARTIS AG (CH) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11180460-B2 | Amino pyrimidine derivatives | BTK, LCK, JAK1 | EGFR 452/4885MEN1 4865/4885KMT2A 1083/4885 |
| US-20110190258-A1 | ARYL BENZYLAMINE COMPOUNDS | UGT2B7, NAT1, CYP2B6 | EGFR 587/4885MEN1 3015/4885KMT2A 806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.