Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 3/20 | 0.55 |
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | BMP4 | P12644 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL805457 | 0.81 | SMPD3 (0.55) | SMPD3AXLCDK2BMP4HSD17B10 | |
| SCHEMBL30579408 | 0.81 | SMPD3 (0.55) | SMPD3AXLCDK2BMP4HSD17B10 | |
| SCHEMBL22792265 | 0.77 | SMPD3 (0.50) | SMPD3AXLCDK2BMP4HSD17B10 | |
| SCHEMBL1243349 | 0.75 | SMPD3 (0.51) | SMPD3AXLCDK2BMP4HSD17B10 | |
| SCHEMBL30579401 | 0.75 | SMPD3 (0.47) | SMPD3AXLCDK2BMP4HSD17B10 | |
| SCHEMBL29518379 | 0.75 | SMPD3 (0.51) | SMPD3AXLCDK2HSD17B10KDM4E | |
| SCHEMBL9461961 | 0.73 | CSF1R (0.49) | SMPD3AXLCDK2BMP4HSD17B10 | |
| SCHEMBL5791049 | 0.71 | SMPD3 (1.00) | SMPD3AXLCDK2BMP4JAK1 | |
| SCHEMBL84781 | 0.71 | SMPD3 (0.60) | SMPD3AXLCDK2BMP4HSD17B10 | |
| SCHEMBL1693808 | 0.71 | AXL (1.00) | SMPD3AXLCDK2BMP4JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252229-A2 | INHIBITORS OF SARM1 | DISARM THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |