Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 6/20 | 1.00 |
| ▸ | AXL | P30530 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | BMP4 | P12644 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7798075 | 0.98 | SMPD3 (0.96) | SMPD3AXLCDK2BMP4IRAK4 | |
| Trifluoroacetic Acid SCHEMBL29977687 | 0.84 | SMPD3 (0.71) | SMPD3AXLCDK2IRAK4HTT | |
| SCHEMBL28947639 | 0.79 | SMPD3 (0.66) | SMPD3AXLCDK2BMP4IRAK4 | |
| SCHEMBL84781 | 0.75 | SMPD3 (0.60) | SMPD3AXLCDK2BMP4IRAK4 | |
| SCHEMBL15336871 | 0.75 | SMPD3 (0.60) | SMPD3AXLCDK2BMP4IRAK4 | |
| SCHEMBL1693808 | 0.75 | AXL (1.00) | SMPD3AXLCDK2BMP4IRAK4 | |
| SCHEMBL24198248 | 0.75 | SMPD3 (0.59) | SMPD3AXLCDK2BMP4IRAK4 | |
| SCHEMBL14699684 | 0.72 | SMPD3 (0.57) | SMPD3AXLCDK2BMP4IRAK4 | |
| SCHEMBL946897 | 0.72 | IRAK4 (0.68) | SMPD3AXLIRAK4HTTHSD11B1 | |
| SCHEMBL30798592 | 0.72 | SMPD3 (0.56) | SMPD3AXLCDK2IRAK4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2802590-B1 | THIENOPYRIMIDINE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2017-03-01 | — | — | EP | claimed |
| US-20020178512-A1 | Oxidation dyeing composition for keratinous fibres comprising a n-(2-hydrobenzene)-carbamate or a n-(2-hydroxy-benzene)-urea and a pyrazolopyrimine, dyeing methods | L'OREAL SA (FR) | 2002-12-05 | — | — | US | claimed |
| EP-1175198-A1 | OXIDATION DYEING COMPOSITION FOR KERATINOUS FIBRES COMPRISING A N-(2-HYDROBENZENE)-CARBAMATE OR A N-(2-HYDROXY-BENZENE)-UREA AND A PYRAZOLOPYRIMINE, DYEING METHODS | L'OREAL (FR) | 2002-01-30 | — | — | EP | claimed |
| US-20010020310-A1 | Compositions for dyeing keratinous fibres, containing 3-aminopyrazolo[1,5-a]pyrimidines, method of dyeing, and novel 3-aminopyrazolo[1,5-a]pyrimidines | L'OREAL S.A. | 2001-09-13 | — | — | US | claimed |
| WO-2001062220-A1 | OXIDATION DYEING COMPOSITION FOR KERATINOUS FIBRES COMPRISING A N-(2-HYDROBENZENE)-CARBAMATE OR A N-(2-HYDROXY-BENZENE)-UREA AND A PYRAZOLOPYRIMINE, DYEING METHODS | L'OREAL (FR) | 2001-08-30 | — | — | WO | claimed |
| US-6248137-B1 | Compositions for dyeing keratinous fibres, containing 3-aminopyrazolo [1,5-a]pyrimidines, method of dyeing and novel 3-aminopyrazolo [1,5-a]pyrimidines | L'OREAL S.A. (FR) | 2001-06-19 | — | — | US | claimed |
| EP-0926149-B1 | Keratin fibre dye composition containing 3-aminopyrazolo-(1,5-a)-pyrimidines, dyeing method , 3-aminopyrazolo-(1,5-a)-pyrimidines and their preparation | OREAL (FR) | 2001-03-07 | — | — | EP | claimed |
| EP-0926149-A1 | Keratin fibre dye composition containing 3-aminopyrazolo-(1,5-a)-pyrimidines, dyeing method , 3-aminopyrazolo-(1,5-a)-pyrimidines and their preparation | L'OREAL (FR) | 1999-06-30 | — | — | EP | claimed |
| JP-11236323-A | — | — | None | — | — | JP | disclosed |
| US-20260092069-A1 | SUBSTITUTED INDAZOLES AS IRAK4 INHIBITORS | ASTRAZENECA AB (SE) | 2026-04-02 | — | — | US | disclosed |
| CN-121537390-A | Preparation method of larotinib | 苏州立新制药有限公司 | 2026-02-17 | — | — | CN | disclosed |
| EP-4674855-A1 | A COMPOUND, AN ORGANIC LIGHT EMITTING DIODE COMPRISING THE DERIVATES, A USE OF THE DIODE, AND A CONSUMER PRODUCT | Noctiluca S.A. (PL) | 2026-01-07 | — | — | EP | disclosed |
| US-12448385-B2 | Substituted indazoles as IRAK4 inhibitors | ASTRAZENECA AB (SE) | 2025-10-21 | — | — | US | disclosed |
| US-20250304567-A1 | PYRROLIDIONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2025-10-02 | — | — | US | disclosed |
| JP-H11236323-A | NEW 3-AMINOPYRAZLO(1, 5-A)PYRIMIDINE, COMPOSITION FOR DYEING KERATINOUS FIBER CONTAINING THE SAME AND DYEING BY USING THE SAME | L'OREAL SA | 1999-08-31 | — | — | JP | disclosed |
| EP-0926149-A1 | Keratin fibre dye composition containing 3-aminopyrazolo-(1,5-a)-pyrimidines, dyeing method , 3-aminopyrazolo-(1,5-a)-pyrimidines and their preparation | L'OREAL (FR) | 1999-06-30 | — | — | EP | disclosed |
| EP-0926149-A1 | Keratin fibre dye composition containing 3-aminopyrazolo-(1,5-a)-pyrimidines, dyeing method , 3-aminopyrazolo-(1,5-a)-pyrimidines and their preparation | L'OREAL (FR) | 1999-06-30 | — | — | EP | disclosed |
| EP-0926149-A1 | Keratin fibre dye composition containing 3-aminopyrazolo-(1,5-a)-pyrimidines, dyeing method , 3-aminopyrazolo-(1,5-a)-pyrimidines and their preparation | L'OREAL (FR) | 1999-06-30 | — | — | EP | disclosed |
| EP-0847271-A1 | PYRAZOLO-(1,5-a)-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND HAIR DYES CONTAINING THESE | L'OREAL (FR) | 1998-06-17 | — | — | EP | disclosed |
| WO-1997049378-A1 | PYRAZOLO-(1,5-a)-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND HAIR DYES CONTAINING THESE | L'OREAL (FR) | 1997-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250304567-A1 | PYRROLIDIONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | NFKBIA, IKBKG, IKBKB | SMPD3 2244/4885AXL 4648/4885CDK2 713/4885 |
| US-20260092069-A1 | SUBSTITUTED INDAZOLES AS IRAK4 INHIBITORS | IRAK3, IRAK4, IRAK2 | SMPD3 3382/4885AXL 1091/4885CDK2 1463/4885 |
| US-12448385-B2 | Substituted indazoles as IRAK4 inhibitors | IRAK4, IRAK1, IRAK2 | SMPD3 3986/4885AXL 1154/4885CDK2 885/4885 |
| US-20020178512-A1 | Oxidation dyeing composition for keratinous fibres comprising a n-(2-hydrobenzene)-carbamate or a n-(2-hydroxy-benzene)-urea and a pyrazolopyrimine, dyeing methods | FH, KRT18, CYB5R3 | SMPD3 4708/4885AXL 1361/4885CDK2 1001/4885 |
| US-20010020310-A1 | Compositions for dyeing keratinous fibres, containing 3-aminopyrazolo[1,5-a]pyrimidines, method of dyeing, and novel 3-aminopyrazolo[1,5-a]pyrimidines | DPYD, KRT18, PNPO | SMPD3 4078/4885AXL 1232/4885CDK2 1090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.