Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 3/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.36 |
| ▸ | PRKDC | P78527 | 4/20 | 0.36 |
| ▸ | MTOR | P42345 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPD | P32754 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29347183 | 0.96 | DDB1 (0.44) | DDB1CRBNPIK3CAPRKDCMTOR | |
| SCHEMBL24669929 | 0.84 | DDB1 (0.43) | DDB1CRBNDRD2SLC6A4MAPT | |
| SCHEMBL26217534 | 0.84 | DDB1 (0.63) | DDB1CRBNPIK3CAPRKDCMTOR | |
| SCHEMBL31748074 | 0.82 | DDB1 (0.43) | DDB1CRBNPIK3CAPRKDCMTOR | |
| SCHEMBL29347184 | 0.82 | DDB1 (0.46) | DDB1CRBNPIK3CAPRKDCMTOR | |
| SCHEMBL25005567 | 0.80 | DDB1 (0.44) | DDB1CRBNPIK3CATP53MAPT | |
| SCHEMBL29346392 | 0.80 | DDB1 (0.61) | DDB1CRBNPIK3CAPRKDCMTOR | |
| SCHEMBL24029813 | 0.80 | CRBN (0.72) | DDB1CRBNALDH1A1CHRM2 | |
| SCHEMBL23945499 | 0.80 | CRBN (0.72) | DDB1CRBNALDH1A1CHRM2 | |
| SCHEMBL20845661 | 0.80 | CRBN (0.72) | DDB1CRBNALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251971-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |