SCHEMBL29347184

SCHEMBL29347184

Cn1c(=O)n(C2CCCCNC2=O)c2ccc(I)cc21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DDB1 Q16531 3/20 0.46
▸ CRBN Q96SW2 3/20 0.46
▸ DRD2 P14416 1/20 0.35
▸ SLC6A4 P31645 1/20 0.35
▸ HPD P32754 3/20 0.34
▸ ALDH1A1 P00352 3/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ PSEN1 P49768 1/20 0.32
▸ PSEN2 P49810 1/20 0.32
▸ KCNH2 Q12809 1/20 0.32
▸ APH1B Q8WW43 1/20 0.32
▸ NCSTN Q92542 1/20 0.32
▸ APH1A Q96BI3 1/20 0.32
▸ PSENEN Q9NZ42 1/20 0.32
▸ PIK3CA P42336 4/20 0.32
▸ PRKDC P78527 4/20 0.32
▸ MTOR P42345 2/20 0.32
▸ TRIM24 O15164 1/20 0.31
▸ NPC1 O15118 1/20 0.31
▸ RAB9A P51151 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29347183 0.86 DDB1 (0.44) DDB1CRBNDRD2SLC6A4HPD
SCHEMBL31748074 0.85 DDB1 (0.43) DDB1CRBNDRD2SLC6A4HPD
SCHEMBL29346392 0.83 DDB1 (0.61) DDB1CRBNALDH1A1KDM4EPIK3CA
SCHEMBL22793979 0.82 DDB1 (0.45) DDB1CRBNDRD2SLC6A4HPD
SCHEMBL26699657 0.80 CRBN (0.72) DDB1CRBNALDH1A1
SCHEMBL24669929 0.80 DDB1 (0.43) DDB1CRBNDRD2SLC6A4HPD
SCHEMBL26217534 0.79 DDB1 (0.63) DDB1CRBNALDH1A1KDM4EPIK3CA
SCHEMBL29347170 0.77 DDB1 (0.45) DDB1CRBNALDH1A1KDM4EPSEN1
SCHEMBL25005567 0.76 DDB1 (0.44) DDB1CRBNHPDALDH1A1KDM4E
SCHEMBL29347196 0.73 KDM4E (0.45) DDB1CRBNALDH1A1KDM4EPIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250388593-A1 CEREBLON E3 LIGASE BINDING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PRODUCTION METHOD THEREFOR MITSUBISHI TANABE PHARMA CORPORATION (JP) 2025-12-25 — — US disclosed
EP-4650348-A1 CEREBLON E3 LIGASE BINDING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PRODUCTION METHOD THEREFOR Mitsubishi Tanabe Pharma Corporation (JP) 2025-11-19 — — EP disclosed
WO-2024150815-A1 CEREBLON E3 LIGASE BINDING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PRODUCTION METHOD THEREFOR 田辺三菱製薬株式会社 2024-07-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250388593-A1 CEREBLON E3 LIGASE BINDING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PRODUCTION METHOD THEREFOR CRBN, CUL1, CBL DDB1 2368/4885CRBN 1/4885DRD2 3845/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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