Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ME2 | P23368 | 1/20 | 0.34 |
| ▸ | ME1 | P48163 | 1/20 | 0.34 |
| ▸ | ME3 | Q16798 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25468376 | 0.91 | HRH3 (0.38) | HRH3KDM4EMAPTALDH1A1PKM | |
| SCHEMBL25481255 | 0.88 | HPGD (0.40) | HRH3MAPTME2ME1ME3 | |
| SCHEMBL25108889 | 0.82 | MAPT (0.38) | KDM4EMAPTRORCSMN1; SMN2 | |
| SCHEMBL25108893 | 0.81 | RORC (0.42) | HRH3RORC | |
| SCHEMBL22790756 | 0.77 | HRH3 (0.58) | HRH3KDM4EMAPTALDH1A1PKM | |
| SCHEMBL25481258 | 0.77 | CHKA (0.36) | HRH3KDM4EMAPTALDH1A1RORC | |
| SCHEMBL25109774 | 0.75 | HRH3 (0.56) | HRH3KDM4EMAPTALDH1A1PKM | |
| SCHEMBL22794340 | 0.74 | HRH3 (0.61) | HRH3KDM4EMAPTALDH1A1PKM | |
| SCHEMBL24513988 | 0.73 | HRH3 (0.57) | HRH3KDM4EMAPTALDH1A1PKM | |
| SCHEMBL25110794 | 0.73 | KDM4E (0.43) | HRH3KDM4EMAPTALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251971-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |