Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.44 |
| ▸ | CHKA | P35790 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RORB | Q92753 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25481719 | 0.95 | BCHE (0.43) | RORCCHKAHDAC3HDAC8AOC3 | |
| SCHEMBL25109016 | 0.95 | BCHE (0.43) | RORCCHKAHDAC3HDAC8AOC3 | |
| SCHEMBL25111118 | 0.95 | BCHE (0.43) | RORCCHKAHDAC3HDAC8AOC3 | |
| SCHEMBL25468550 | 0.91 | KDM4E (0.45) | RORCRORBDPP7 | |
| SCHEMBL25483142 | 0.90 | RORC (0.42) | RORCCHKAHDAC3HDAC8AOC3 | |
| SCHEMBL22794089 | 0.86 | HRH3 (0.43) | RORCRORB | |
| SCHEMBL22794295 | 0.86 | BCHE (0.41) | KMT2ADPP7 | |
| SCHEMBL25468414 | 0.86 | HRH3 (0.43) | RORCRORB | |
| SCHEMBL25468417 | 0.86 | HRH3 (0.43) | RORCRORB | |
| SCHEMBL25111135 | 0.85 | BCHE (0.41) | RORCCHKAHDAC3HDAC8AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125804-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |
| WO-2020251971-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |