Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 5/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24607440 | 0.88 | PIK3CD (0.70) | PIK3CDCYP2D6TSHRUSP2CYP1A2 | |
| SCHEMBL29088302 | 0.86 | TSHR (0.60) | PIK3CDCYP2D6TSHRUSP2CYP1A2 | |
| SCHEMBL23696325 | 0.85 | CYP2D6 (0.58) | CYP2D6TSHRUSP2CYP1A2HIF1A | |
| SCHEMBL23572026 | 0.84 | PIK3CD (0.58) | PIK3CDCYP2D6TSHRUSP2CYP1A2 | |
| SCHEMBL24508736 | 0.83 | PIK3CD (0.46) | PIK3CDCYP2D6TSHRUSP2CYP1A2 | |
| SCHEMBL25928035 | 0.83 | CYP2D6 (0.57) | CYP2D6TSHRUSP2CYP1A2HIF1A | |
| SCHEMBL23945317 | 0.82 | CYP2D6 (0.56) | CYP2D6TSHRUSP2CYP1A2HIF1A | |
| SCHEMBL22848882 | 0.81 | CYP2D6 (0.44) | PIK3CDCYP2D6TSHRUSP2CYP1A2 | |
| SCHEMBL22848880 | 0.81 | CYP2D6 (0.54) | CYP2D6TSHRUSP2CYP1A2HIF1A | |
| SCHEMBL21787313 | 0.81 | CYP2D6 (0.54) | PIK3CDCYP2D6TSHRUSP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127278-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2020251971-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |