Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 12/20 | 0.54 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | USP2 | O75604 | 7/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23328300 | 0.83 | CYP2D6 (0.39) | CYP2D6TSHRUSP2CYP1A2CYP2C9 | |
| SCHEMBL22794820 | 0.81 | PIK3CD (0.62) | CYP2D6TSHRUSP2CYP1A2CYP2C9 | |
| SCHEMBL29088302 | 0.81 | TSHR (0.60) | CYP2D6TSHRUSP2CYP1A2CYP2C9 | |
| SCHEMBL23696325 | 0.80 | CYP2D6 (0.58) | CYP2D6TSHRUSP2CYP1A2CYP2C9 | |
| SCHEMBL25928035 | 0.78 | CYP2D6 (0.57) | CYP2D6TSHRUSP2CYP1A2CYP2C9 | |
| SCHEMBL22849040 | 0.78 | GPR183 (0.40) | CYP2D6USP2CYP2C19 | |
| SCHEMBL23945317 | 0.77 | CYP2D6 (0.56) | CYP2D6TSHRUSP2CYP1A2CYP2C9 | |
| SCHEMBL23945973 | 0.76 | CYP2D6 (0.54) | CYP2D6TSHRUSP2CYP1A2CYP2C9 | |
| SCHEMBL22848880 | 0.76 | CYP2D6 (0.54) | CYP2D6TSHRUSP2CYP1A2CYP2C9 | |
| SCHEMBL25603399 | 0.76 | CYP2D6 (0.54) | CYP2D6TSHRUSP2CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11149032-B2 | Inhibitors of mutant isocitrate dehydrogenases and compositions and methods thereof | ISOCURE BIOSCIENCES INC. (US) | 2021-10-19 | — | — | US | disclosed |
| US-20200071309-A1 | INHIBITORS OF MUTANT ISOCITRATE DEHYDROGENASES AND COMPOSITIONS AND METHODS THEREOF | ISOCURE BIOSCIENCES INC (US) | 2020-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11149032-B2 | Inhibitors of mutant isocitrate dehydrogenases and compositions and methods thereof | IDH1, IDH2, IDH3A | CYP2D6 1138/4885TSHR 4834/4885USP2 1440/4885 |
| US-20200071309-A1 | INHIBITORS OF MUTANT ISOCITRATE DEHYDROGENASES AND COMPOSITIONS AND METHODS THEREOF | IDH1, IDH2, IDH3A | CYP2D6 1138/4885TSHR 4834/4885USP2 1440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.