Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 3/20 | 0.56 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.56 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.56 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26108748 | 0.89 | NPC1 (0.50) | NR1H2NR1H3DGAT1PLCG1MEN1 | |
| SCHEMBL12405422 | 0.80 | NR1H2 (0.56) | NR1H2NR1H3MEN1KMT2ACYP1A2 | |
| SCHEMBL1528410 | 0.80 | NR1H2 (0.56) | NR1H2NR1H3MEN1KMT2AALDH1A1 | |
| SCHEMBL15660670 | 0.80 | ALDH1A1 (0.46) | NR1H2NR1H3ALDH1A1GAANPC1 | |
| SCHEMBL1686718 | 0.79 | NR1H2 (0.61) | NR1H2NR1H3DGAT1MEN1KMT2A | |
| SCHEMBL6029897 | 0.78 | ALDH1A1 (0.64) | NR1H2NR1H3DGAT1MEN1KMT2A | |
| SCHEMBL2769054 | 0.78 | JAK2 (0.49) | NPC1RAB9ALMNAJAK2 | |
| SCHEMBL15299350 | 0.76 | HDAC3 (0.60) | NR1H2NR1H3DGAT1PLCG1MEN1 | |
| SCHEMBL23062798 | 0.76 | NPC1 (0.58) | DGAT1KMT2AALDH1A1MAPTIKBKB | |
| SCHEMBL19127978 | 0.76 | KDM4E (0.56) | MEN1KMT2AALDH1A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2260031-B1 | COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2015-10-07 | — | — | EP | disclosed |
| US-8716483-B2 | Compounds that are ERK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-05-06 | — | — | US | disclosed |
| US-20110189192-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME LLC | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110189192-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MAPK1, MAPK4, MAPK10 | NR1H2 1153/4885NR1H3 1278/4885DGAT1 1976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.