Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.70 |
| ▸ | TP53 | P04637 | 6/20 | 0.70 |
| ▸ | HPGD | P15428 | 7/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.60 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22796564 | 0.91 | TP53 (0.85) | LMNATP53HPGDKDM4EALDH1A1 | |
| SCHEMBL22796562 | 0.89 | HPGD (0.57) | LMNATP53HPGDKDM4EALDH1A1 | |
| SCHEMBL22796708 | 0.89 | LMNA (0.65) | LMNATP53HPGDKDM4EALDH1A1 | |
| SCHEMBL902657 | 0.88 | TP53 (0.60) | LMNATP53HPGDKDM4EALDH1A1 | |
| SCHEMBL22680749 | 0.86 | LMNA (0.70) | LMNATP53HPGDKDM4EALDH1A1 | |
| SCHEMBL15572020 | 0.85 | LMNA (0.76) | LMNATP53HPGDKDM4EALDH1A1 | |
| SCHEMBL13236239 | 0.85 | LMNA (0.68) | LMNATP53HPGDKDM4EALDH1A1 | |
| SCHEMBL902821 | 0.85 | LMNA (0.64) | LMNATP53HPGDKDM4EALDH1A1 | |
| SCHEMBL15573905 | 0.84 | HPGD (0.68) | LMNATP53HPGDKDM4EALDH1A1 | |
| SCHEMBL902576 | 0.84 | LMNA (0.58) | LMNATP53HPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252195-A1 | TELOMERASE REVERSE TRANSCRIPTASE DEGRADERS AND METHODS OF USE THEREOF | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2020-12-17 | — | — | WO | disclosed |