Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27752052 | 0.85 | ALDH1A1 (0.39) | MAPTALDH1A1 | |
| SCHEMBL22799263 | 0.83 | MAPT (0.43) | MAPTALDH1A1KDM4EGAACYP3A4 | |
| SCHEMBL17928591 | 0.79 | ALDH1A1 (0.47) | ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL15790873 | 0.79 | MAPT (0.46) | MAPTALDH1A1KDM4EGAACYP3A4 | |
| SCHEMBL446501 | 0.79 | MAPT (0.64) | MAPTALDH1A1KDM4EGAACYP3A4 | |
| SCHEMBL1816298 | 0.79 | MAPT (0.41) | MAPTALDH1A1KDM4EGAACYP3A4 | |
| SCHEMBL1816297 | 0.79 | MAPT (0.41) | MAPTALDH1A1KDM4EGAACYP3A4 | |
| Iodide SCHEMBL30309834 | 0.78 | MAPT (0.62) | MAPTALDH1A1KDM4EGAACYP3A4 | |
| Hydrochloric Acid SCHEMBL9704969 | 0.78 | MAPT (0.62) | MAPTALDH1A1KDM4EGAACYP3A4 | |
| Hydrochloric Acid SCHEMBL27605420 | 0.78 | MAPT (0.62) | MAPTALDH1A1KDM4EGAACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252151-A1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. (US) | 2020-12-17 | — | — | WO | disclosed |