Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | TEK | Q02763 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | KRAS | P01116 | 1/20 | 0.31 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.31 |
| ▸ | USP1 | O94782 | 2/20 | 0.31 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.31 |
| ▸ | GCGR | P47871 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22702052 | 0.93 | FYN (0.39) | FYNCTSAMAPK10DYRK1ANFATC1 | |
| SCHEMBL18375348 | 0.83 | LRRK2 (0.39) | MAPK10DYRK1ANFATC1GSK3BLRRK2 | |
| SCHEMBL22702214 | 0.74 | EPHX1 (0.38) | FYNMAPK10LRRK2TEKKCNH2 | |
| SCHEMBL18367721 | 0.73 | CYP2A6 (0.46) | USP1WDR48 | |
| SCHEMBL26563732 | 0.72 | MAPT (0.46) | GSK3BRPS6KA3GCGR | |
| SCHEMBL14493338 | 0.71 | RPS6KA3 (0.41) | FYNMAPK10DYRK1ANFATC1GSK3B | |
| SCHEMBL18367725 | 0.70 | GABRA1 (0.38) | RPS6KA3SOS1USP1WDR48TRPA1 | |
| SCHEMBL6318808 | 0.69 | PDCD1 (0.50) | USP1WDR48 | |
| SCHEMBL8819417 | 0.69 | CA12 (0.51) | MAPK10TEKRPS6KA3GCGRKCNH2 | |
| SCHEMBL23674396 | 0.67 | MAPT (0.41) | MAPK10TEKGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252151-A1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. (US) | 2020-12-17 | — | — | WO | disclosed |