Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31184024 | 0.82 | KDM4E (0.45) | MAPTKDM4ETHRBPTPN2PTPN1 | |
| SCHEMBL20385872 | 0.82 | KDM4E (0.45) | MAPTKDM4ETHRBPTPN2PTPN1 | |
| SCHEMBL16914367 | 0.82 | KDM4E (0.45) | MAPTKDM4ETHRBPTPN2PTPN1 | |
| SCHEMBL22798969 | 0.81 | USP2 (0.41) | MAPTKDM4ETHRBPTPN2PTPN1 | |
| SCHEMBL22799096 | 0.78 | USP2 (0.41) | MAPTKDM4ETHRBPTPN2PTPN1 | |
| SCHEMBL22799622 | 0.77 | EPHX2 (0.40) | MAPTKDM4ETHRBPTPN2PTPN1 | |
| SCHEMBL28804271 | 0.75 | EPHX2 (0.40) | MAPTKDM4ETHRBPTPN2PTPN1 | |
| SCHEMBL22799010 | 0.74 | USP2 (0.42) | HPGDUSP2SMN1; SMN2EPHX1HRH3 | |
| SCHEMBL24089120 | 0.73 | USP2 (0.50) | MAPTKDM4ETHRBHPGDUSP2 | |
| SCHEMBL29930338 | 0.73 | MAPT (0.40) | MAPTKDM4ETHRBPTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115448923-B | Pyrimidine-fused ring compound, preparation method and application thereof | 上海青煜医药科技有限公司 | 2024-03-22 | — | — | CN | disclosed |
| CN-110156786-B | Pyrimido-cyclic compounds, process for their preparation and their use | 青煜医药研发(上海)有限公司 | 2022-06-03 | — | — | CN | disclosed |
| EP-3753941-A1 | PYRIMIDINE-FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Shanghai Blueray Biopharma Co., Ltd. (CN) | 2020-12-23 | — | — | EP | disclosed |