Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22799622 | 0.87 | EPHX2 (0.40) | EPHX2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL16914421 | 0.82 | USP2 (0.43) | EPHX2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL21852145 | 0.82 | USP2 (0.43) | EPHX2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL22799022 | 0.80 | — | — | |
| SCHEMBL29715539 | 0.80 | USP2 (0.37) | EPHX2USP2SMN1; SMN2GPR119RECQL | |
| SCHEMBL22799010 | 0.78 | USP2 (0.42) | EPHX2USP2SMN1; SMN2HPGDHRH3 | |
| SCHEMBL22799064 | 0.76 | USP2 (0.47) | EPHX2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL22799173 | 0.75 | MAPT (0.42) | EPHX2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL1474868 | 0.74 | USP2 (0.49) | EPHX2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL24089120 | 0.72 | USP2 (0.50) | EPHX2USP2SMN1; SMN2GPR119HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115448923-A | Pyrimido-cyclic compounds, process for their preparation and their use | 青煜医药研发(上海)有限公司 | 2022-12-09 | — | — | CN | disclosed |
| CN-110156786-B | Pyrimido-cyclic compounds, process for their preparation and their use | 青煜医药研发(上海)有限公司 | 2022-06-03 | — | — | CN | disclosed |