SCHEMBL22799488

SCHEMBL22799488

CC(C)(C)c1ccc2c(c1)C1(c3ccccc3-c3cc(Cl)ccc31)c1cc(C(C)(C)C)ccc1C2(C)C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 7/20 0.48
NPC1 O15118 1/20 0.36
ALDH1A1 P00352 1/20 0.36
PLA2G1B P04054 1/20 0.36
NFKB1 P19838 1/20 0.36
CASP3 P42574 1/20 0.36
RAB9A P51151 1/20 0.36
NFKB2 Q00653 1/20 0.36
RELA Q04206 1/20 0.36
SENP8 Q96LD8 1/20 0.36
SENP7 Q9BQF6 1/20 0.36
SENP6 Q9GZR1 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
ATG4B Q9Y4P1 1/20 0.36
PGR P06401 2/20 0.34
AKR1A1 P14550 1/20 0.33
AKR1B1 P15121 1/20 0.33
MDM2 Q00987 2/20 0.32
TP53 P04637 1/20 0.32
CCR9 P51686 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22797355 0.93 PDK2 (0.43) PDK2NPC1ALDH1A1PLA2G1BNFKB1
SCHEMBL21881099 0.85 PDK2 (0.49) PDK2NPC1ALDH1A1PLA2G1BNFKB1
SCHEMBL22797230 0.85 PDK2 (0.45) PDK2NPC1ALDH1A1PLA2G1BNFKB1
SCHEMBL30844881 0.85 PDK2 (0.54) PDK2PGRAKR1A1AKR1B1S100A4
SCHEMBL21923924 0.85 PDK2 (0.54) PDK2PGRAKR1A1AKR1B1S100A4
SCHEMBL22799495 0.82 PDK2 (0.41) PDK2NPC1ALDH1A1PLA2G1BNFKB1
SCHEMBL24730198 0.82 PDK2 (0.49) PDK2PGRAKR1A1AKR1B1TP53
SCHEMBL19656609 0.82 ALDH1A1 (0.52) PDK2NPC1ALDH1A1PLA2G1BNFKB1
SCHEMBL19849937 0.80 PDK2 (0.59) PDK2PGRAKR1A1AKR1B1S100A4
SCHEMBL12685311 0.80 PDK2 (0.62) PDK2AKR1A1AKR1B1TP53S100A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020248943-A1 NITROGEN-CONTAINING COMPOUND, ELECTRONIC COMPONENT AND ELECTRONIC DEVICE 陕西莱特光电材料股份有限公司 2020-12-17 WO disclosed