Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 10/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.62 |
| ▸ | MAPK6 | Q16659 | 5/20 | 0.62 |
| ▸ | MAPKAPK3 | Q16644 | 4/20 | 0.62 |
| ▸ | TTK | P33981 | 2/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.60 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.57 |
| ▸ | PIM1 | P11309 | 3/20 | 0.56 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22819421 | 0.86 | MAP2K4 (1.00) | MAP2K4MAPK1MAPK6MAPKAPK3TTK | |
| SCHEMBL14514462 | 0.82 | PDGFRB (0.63) | MAP2K4MAP3K5LRRK2 | |
| SCHEMBL22819366 | 0.81 | MAP2K4 (1.00) | MAP2K4MAPK1MAPK6MAPKAPK3TTK | |
| SCHEMBL2860093 | 0.79 | MAP2K4 (0.71) | MAP2K4MAPK1MAPK6MAPKAPK3MAPKAPK2 | |
| SCHEMBL5377653 | 0.79 | MAP2K4 (0.73) | MAP2K4MAPK1MAPK6MAPKAPK3TTK | |
| SCHEMBL5801740 | 0.79 | MAP2K4 (0.65) | MAP2K4MAPK1MAPK6MAPKAPK3TTK | |
| SCHEMBL5374141 | 0.78 | MAP3K5 (0.57) | MAP2K4MAPK1MAPK6MAPKAPK3TTK | |
| SCHEMBL22801797 | 0.77 | MAP2K4 (1.00) | MAP2K4MAPK1MAPK6MAPKAPK3MAPK8 | |
| SCHEMBL5374481 | 0.77 | MAP2K4 (0.67) | MAP2K4MAPK1MAPK6MAPKAPK3TTK | |
| SCHEMBL5382810 | 0.76 | MAP2K4 (0.65) | MAP2K4MAPK1MAPK6MAPKAPK3TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11370770-B2 | 3-arylindazoles as selective MEK4 inhibitors | NORTHWESTERN UNIVERSITY (US) | 2022-06-28 | — | — | US | disclosed |
| US-11370770-B2 | 3-arylindazoles as selective MEK4 inhibitors | NORTHWESTERN UNIVERSITY (US) | 2022-06-28 | — | — | US | disclosed |
| US-20200399241-A1 | 3-ARYLINDAZOLES AS SELECTIVE MEK4 INHIBITORS | NORTHWESTERN UNIVERSITY (US) | 2020-12-24 | — | — | US | disclosed |
| US-20200399241-A1 | 3-ARYLINDAZOLES AS SELECTIVE MEK4 INHIBITORS | NORTHWESTERN UNIVERSITY (US) | 2020-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200399241-A1 | 3-ARYLINDAZOLES AS SELECTIVE MEK4 INHIBITORS | MAP4K3, MAPK4, MAP3K4 | MAP2K4 39/4885MAPK1 32/4885MAPK6 42/4885 |
| US-11370770-B2 | 3-arylindazoles as selective MEK4 inhibitors | MAP4K3, MAPK4, MAP3K4 | MAP2K4 39/4885MAPK1 32/4885MAPK6 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.