Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 9/20 | 0.65 |
| ▸ | TTK | P33981 | 3/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.55 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.55 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.55 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.55 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2858476 | 0.88 | MAP2K4 (0.68) | MAP2K4TTKMAPK1MAPK6MAPKAPK3 | |
| Ethylene SCHEMBL27536148 | 0.86 | MAP2K4 (0.65) | MAP2K4TTKMAPK1MAPK6MAPKAPK3 | |
| SCHEMBL5374481 | 0.85 | MAP2K4 (0.67) | MAP2K4TTKMAPK8MAPK1MAPK6 | |
| SCHEMBL3756031 | 0.85 | MAP2K4 (0.67) | MAP2K4TTKMAPK8MAPK1MAPK6 | |
| SCHEMBL2868599 | 0.85 | MAP2K4 (0.57) | MAP2K4TTKMAPK8MAPK1MAPK6 | |
| SCHEMBL2869817 | 0.85 | MAP2K4 (0.54) | MAP2K4TTKMAPK1MAPK6MAPKAPK3 | |
| Hydrochloric Acid SCHEMBL27750633 | 0.84 | MAP2K4 (0.65) | MAP2K4TTKMAPK8MAPK1MAPK6 | |
| SCHEMBL2860913 | 0.84 | MAP2K4 (0.61) | MAP2K4TTKMAPK8MAPK1MAPK6 | |
| SCHEMBL5377609 | 0.81 | MAP2K4 (0.65) | MAP2K4TTKMAPK8MAPK1MAPK6 | |
| SCHEMBL27558704 | 0.81 | TTK (0.56) | MAP2K4TTKCHEK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618093-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | Signal Pharmaceuticals LLC (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004094388-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-11-04 | — | — | WO | disclosed |