Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29848882 | 0.78 | PARP1 (0.33) | PARP1MAPTAURKAAURKBDAO | |
| SCHEMBL24823617 | 0.77 | EIF4A3 (0.36) | PARP1AURKAAURKBCHEK1MAP4K4 | |
| SCHEMBL9625932 | 0.77 | GABRA1 (0.46) | PARP1DAOKDM4EALDH1A1LMNA | |
| SCHEMBL22963000 | 0.77 | AURKA (0.43) | PARP1MAPTAURKAAURKBDYRK1A | |
| SCHEMBL27401155 | 0.77 | SIRT2 (0.38) | PARP1MAPTAURKAAURKBCHEK1 | |
| SCHEMBL1123742 | 0.75 | GRIN2D (0.33) | PARP1MAPT | |
| SCHEMBL20869412 | 0.74 | PDE3B (0.44) | MAPTKDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL1106174 | 0.74 | JAK2 (0.31) | PARP1 | |
| SCHEMBL1106163 | 0.74 | JAK2 (0.32) | PARP1MAPT | |
| SCHEMBL24823773 | 0.72 | NOTUM (0.33) | KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252240-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | IFM DUE, INC. (US) | 2020-12-17 | — | — | WO | disclosed |