Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.50 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.50 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 10/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6619488 | 0.86 | TXNRD1 (0.68) | TXNRD1TXNRD3TXNRD2MAPTALDH1A1 | |
| SCHEMBL30414974 | 0.86 | TXNRD1 (0.68) | TXNRD1TXNRD3TXNRD2MAPTALDH1A1 | |
| SCHEMBL13015521 | 0.81 | TXNRD1 (0.75) | TXNRD1TXNRD3TXNRD2MAPTALDH1A1 | |
| SCHEMBL17099743 | 0.79 | TXNRD1 (0.50) | TXNRD1TXNRD3TXNRD2MAPTALDH1A1 | |
| SCHEMBL8403306 | 0.79 | TXNRD1 (0.50) | TXNRD1TXNRD3TXNRD2MAPTALDH1A1 | |
| SCHEMBL30329884 | 0.76 | CYP1A2 (0.51) | TXNRD1TXNRD3TXNRD2MAPTALDH1A1 | |
| SCHEMBL11262989 | 0.76 | TXNRD1 (0.46) | TXNRD1TXNRD3TXNRD2MAPTALDH1A1 | |
| SCHEMBL30329662 | 0.76 | MAPT (0.49) | TXNRD1TXNRD3TXNRD2MAPTALDH1A1 | |
| SCHEMBL30329969 | 0.76 | MAPT (0.49) | TXNRD1TXNRD3TXNRD2MAPTALDH1A1 | |
| SCHEMBL13015522 | 0.76 | TXNRD1 (0.46) | TXNRD1TXNRD3TXNRD2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112469713-B | Aryl phosphorus oxide derivative inhibitor, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-116234556-A | Crystal form of aryl phosphorus oxide derivative free alkali and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2023-06-06 | — | — | CN | disclosed |
| WO-2023011610-A1 | BENZODIOXANE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 南京红云生物科技有限公司 | 2023-02-09 | — | — | WO | disclosed |
| WO-2022127807-A1 | CRYSTAL FORM OF ARYL PHOSPHORUS OXIDE DERIVATIVE FREE BASE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 江苏豪森药业集团有限公司 | 2022-06-23 | — | — | WO | disclosed |
| WO-2022127807-A1 | CRYSTAL FORM OF ARYL PHOSPHORUS OXIDE DERIVATIVE FREE BASE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 江苏豪森药业集团有限公司 | 2022-06-23 | — | — | WO | disclosed |
| CN-114644654-A | Oxidized aryl phosphorus derivative, acid salt or crystal form thereof, and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2022-06-21 | — | — | CN | disclosed |
| CN-112469713-A | Aryl phosphorus oxide derivative inhibitor, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-03-09 | — | — | CN | disclosed |
| WO-2020253860-A1 | ARYL PHOSPHORUS OXIDE DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 江苏豪森药业集团有限公司 | 2020-12-24 | — | — | WO | disclosed |
| WO-2020253860-A1 | ARYL PHOSPHORUS OXIDE DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 江苏豪森药业集团有限公司 | 2020-12-24 | — | — | WO | disclosed |