Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Mannitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mannitol SCHEMBL5794749 | 0.95 | PDE4A (0.60) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Adonitol SCHEMBL27759312 | 0.95 | PDE4A (0.58) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Sorbitol SCHEMBL8840893 | 0.93 | PDE4A (0.58) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Xylitol SCHEMBL6859096 | 0.92 | PDE4A (0.56) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Sorbitol SCHEMBL8158205 | 0.91 | PDE4A (0.56) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Gluconic Acid SCHEMBL27466658 | 0.91 | PDE4A (0.83) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Gluconic Acid SCHEMBL872998 | 0.91 | PDE4A (0.83) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Gluconic Acid SCHEMBL30528009 | 0.91 | PDE4A (0.83) | PDE4AUSP2SLCO1B1LMNATP53 | |
| E968 SCHEMBL28446897 | 0.89 | TP53 (0.65) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Gluconic Acid SCHEMBL5095328 | 0.89 | PDE4A (0.79) | PDE4AUSP2SLCO1B1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117462509-A | Enteric soft gelatin capsule | R·P·谢勒技术有限公司 | 2024-01-30 | — | — | CN | disclosed |
| CN-112105334-B | Enteric soft gelatin capsule | R.P.谢勒技术有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-114983936-A | Octreotide acetate injection with good stability as well as preparation method and application thereof | 本溪恒康制药有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-114845569-A | Delayed release softgel capsules in higher PH environments | R.P.谢勒技术有限公司 | 2022-08-02 | — | — | CN | disclosed |
| EP-3986160-A1 | EUTECTIC EXTRACTION OF SOLIDS | Givaudan SA (CH) | 2022-04-27 | — | — | EP | disclosed |
| WO-2020254579-A1 | EUTECTIC EXTRACTION OF SOLIDS | GIVAUDAN SA (CH) | 2020-12-24 | — | — | WO | disclosed |
| CN-112105334-A | Enteric soft gelatin capsule | R.P.谢勒技术有限公司 | 2020-12-18 | — | — | CN | disclosed |
| CN-111867399-A | Enteric soft gelatin capsule | R.P.谢勒技术有限公司 | 2020-10-30 | — | — | CN | disclosed |
| CN-110960551-A | Novel electrolyte sorbitol chiral resuscitation medicine composition | 刘力 | 2020-04-07 | — | — | CN | disclosed |
| CN-110934888-A | Novel electrolytic glycoside therapeutic pharmaceutical composition | 刘力 | 2020-03-31 | — | — | CN | disclosed |
| CN-102327617-B | Sulfoalkyl ether-cyclodextrin (SAE-CD) composition and preparation method thereof | CYDEX PHARMACEUTICALS INC | 2014-08-20 | — | — | CN | disclosed |
| CN-103221525-A | Hard surface cleaners comprising low VOC, low odor alkanolamines | DOW GLOBAL TECHNOLOGIES INC | 2013-07-24 | — | — | CN | disclosed |
| CN-102327617-A | Sulfoalkyl ether cyclodextrin compositions and its preparation method | CYDEX INC | 2012-01-25 | — | — | CN | disclosed |
| CN-102264888-A | Polymeric aluminum compositions | — | 2011-11-30 | — | — | CN | disclosed |
| CN-101365459-B | Sulfoalkyl ether cyclodextrin compositions and methods for making same | CYDEX PHARMACEUTICALS, INC. (US) | 2011-11-30 | — | — | CN | disclosed |
| CN-101365459-A | Sulfoalkyl ether cyclodextrin compositions and methods for making same | CYDEX INC (US) | 2009-02-11 | — | — | CN | disclosed |