Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Sorbitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mannitol SCHEMBL22804492 | 0.93 | PDE4A (0.65) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Sorbitol SCHEMBL8158205 | 0.89 | PDE4A (0.56) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Mannitol SCHEMBL5794749 | 0.88 | PDE4A (0.60) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Adonitol SCHEMBL27759312 | 0.88 | PDE4A (0.58) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Xylitol SCHEMBL6859096 | 0.86 | PDE4A (0.56) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Gluconic Acid SCHEMBL27466658 | 0.84 | PDE4A (0.83) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Gluconic Acid SCHEMBL30528009 | 0.84 | PDE4A (0.83) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Gluconic Acid SCHEMBL872998 | 0.84 | PDE4A (0.83) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Mannitol SCHEMBL8594260 | 0.84 | USP2 (0.68) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Mannitol SCHEMBL27396762 | 0.84 | USP2 (0.68) | PDE4AUSP2SLCO1B1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0769082-A1 | BINDER TREATED FIBROUS WEBS AND PRODUCTS | WEYERHAEUSER COMPANY (US) | 1997-04-23 | — | — | EP | disclosed |
| WO-1996031644-A1 | BINDER TREATED FIBROUS WEBS AND PRODUCTS | WEYERHAEUSER COMPANY (US) | 1996-10-10 | — | — | WO | disclosed |