Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2280453 | 1.00 | DGAT1 (0.32) | DGAT1KLKB1BRD4CREBBP | |
| SCHEMBL2280452 | 1.00 | DGAT1 (0.32) | DGAT1KLKB1BRD4CREBBP | |
| SCHEMBL2277476 | 0.92 | DGAT1 (0.35) | DGAT1KLKB1BRD4CREBBP | |
| SCHEMBL2277471 | 0.92 | DGAT1 (0.35) | DGAT1KLKB1BRD4CREBBP | |
| SCHEMBL2277480 | 0.92 | DGAT1 (0.35) | DGAT1KLKB1BRD4CREBBP | |
| SCHEMBL2279891 | 0.90 | DGAT1 (0.34) | DGAT1KLKB1BRD4CREBBP | |
| SCHEMBL2279887 | 0.90 | DGAT1 (0.34) | DGAT1KLKB1BRD4CREBBP | |
| SCHEMBL2279894 | 0.90 | DGAT1 (0.34) | DGAT1KLKB1BRD4CREBBP | |
| SCHEMBL2273028 | 0.89 | DGAT1 (0.36) | DGAT1KLKB1BRD4CREBBP | |
| SCHEMBL2277648 | 0.88 | KLKB1 (0.41) | DGAT1KLKB1BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | disclosed |
| US-8008298-B2 | Pyrrolopyrazine kinase inhibitors | Roche Palo Alto (US) | 2011-08-30 | — | — | US | disclosed |
| US-20100267666-A1 | Pyrrolopyrazine kinase inhibitors | ROCHE PALO ALTO LLC | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267666-A1 | Pyrrolopyrazine kinase inhibitors | SYK, ZAP70, TYK2 | DGAT1 4740/4885KLKB1 1991/4885BRD4 546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.