Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29542941 | 0.81 | MEN1 (0.45) | MEN1KMT2ATSHRLMNASMN1; SMN2 | |
| SCHEMBL20041908 | 0.70 | DDB1 (0.44) | MEN1KMT2ATSHRSMN1; SMN2NPC1 | |
| SCHEMBL19559384 | 0.70 | DDB1 (0.44) | MEN1KMT2ATSHRSMN1; SMN2NPC1 | |
| SCHEMBL19559433 | 0.69 | DDB1 (0.43) | MEN1KMT2ATSHRSMN1; SMN2NPC1 | |
| SCHEMBL1350682 | 0.69 | SMN1; SMN2 (0.47) | MEN1KMT2ATSHRLMNASMN1; SMN2 | |
| SCHEMBL1350684 | 0.69 | SMN1; SMN2 (0.47) | MEN1KMT2ATSHRLMNASMN1; SMN2 | |
| SCHEMBL1350680 | 0.69 | SMN1; SMN2 (0.47) | MEN1KMT2ATSHRLMNASMN1; SMN2 | |
| SCHEMBL23126457 | 0.68 | SMN1; SMN2 (0.47) | MEN1KMT2ATSHRLMNASMN1; SMN2 | |
| SCHEMBL31681185 | 0.68 | TSHR (0.47) | MEN1KMT2ATSHRLMNASMN1; SMN2 | |
| SCHEMBL16914380 | 0.68 | SMN1; SMN2 (0.47) | MEN1KMT2ATSHRLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3986886-A2 | SUBSTITUTED PYRROLIDINE AMIDES V | Grünenthal GmbH (DE) | 2022-04-27 | — | — | EP | disclosed |
| WO-2020254552-A2 | SUBSTITUTED PYRROLIDINE AMIDES V | Grünenthal GmbH (DE) | 2020-12-24 | — | — | WO | disclosed |