Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.60 |
| ▸ | FGFR4 | P22455 | 10/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 3/20 | 0.41 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29733429 | 0.85 | FGFR1 (0.56) | FGFR1FGFR4CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL18131773 | 0.78 | FGFR4 (0.80) | FGFR1FGFR4CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22828278 | 0.77 | FGFR1 (0.48) | FGFR1FGFR4CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL18131770 | 0.76 | FGFR4 (0.81) | FGFR1FGFR4CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL28696599 | 0.76 | FGFR1 (0.47) | FGFR1FGFR4CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4074720 | 0.76 | DEGS1 (0.55) | NPC1RAB9AMITFTP53GAA | |
| SCHEMBL22807283 | 0.76 | FGFR3 (0.45) | FGFR1FGFR4CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22807284 | 0.76 | FGFR3 (0.45) | FGFR1FGFR4CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL29489954 | 0.76 | FGFR3 (0.45) | FGFR1FGFR4CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL18131765 | 0.76 | FGFR1 (0.45) | FGFR1FGFR4CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3986405-A1 | COMPOUNDS FOR INHIBITING FGFR4 | Terns Pharmaceuticals, Inc. (US) | 2022-04-27 | — | — | EP | disclosed |
| WO-2020257527-A1 | COMPOUNDS FOR INHIBITING FGFR4 | Terns, Inc. (US) | 2020-12-24 | — | — | WO | disclosed |