Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 11/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 13/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 3/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29733429 | 0.91 | FGFR1 (0.56) | FGFR1FGFR4CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22807293 | 0.77 | FGFR1 (0.60) | FGFR1FGFR4CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8228538 | 0.73 | DEGS1 (0.49) | NPC1MITFTP53GAARAB9A | |
| SCHEMBL29211424 | 0.69 | ANO1 (0.40) | CYP2C9GAA | |
| SCHEMBL23510760 | 0.69 | GSK3B (0.42) | ABCB1NPC1MITFTP53GAA | |
| SCHEMBL13876322 | 0.68 | GRIN2B (0.47) | TP53 | |
| SCHEMBL15879088 | 0.68 | GSK3B (0.42) | NPC1RAB9A | |
| SCHEMBL31599569 | 0.68 | GRIN2B (0.47) | TP53 | |
| SCHEMBL18131773 | 0.68 | FGFR4 (0.80) | FGFR1FGFR4CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2116624 | 0.67 | GSK3B (0.44) | ABCB1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020257527-A1 | COMPOUNDS FOR INHIBITING FGFR4 | Terns, Inc. (US) | 2020-12-24 | — | — | WO | disclosed |