Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.61 |
| ▸ | RHOC | P08134 | 1/20 | 0.37 |
| ▸ | RHOA | P61586 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20595204 | 0.88 | SCN9A (0.78) | SCN9ARHOCRHOAPTK2MAPT | |
| SCHEMBL30449602 | 0.88 | SCN9A (0.78) | SCN9ARHOCRHOAPTK2MAPT | |
| SCHEMBL22798304 | 0.85 | SCN9A (0.82) | SCN9ARHOCRHOARIPK1SMN1; SMN2 | |
| SCHEMBL30450216 | 0.85 | SCN9A (0.82) | SCN9ARHOCRHOARIPK1SMN1; SMN2 | |
| SCHEMBL2718458 | 0.78 | SCN9A (0.50) | SCN9AMAPTMAPK8RIPK1SMN1; SMN2 | |
| SCHEMBL22798237 | 0.76 | SCN9A (0.79) | SCN9ARHOCRHOASMN1; SMN2MEN1 | |
| SCHEMBL22798213 | 0.75 | SCN9A (1.00) | SCN9ARHOCRHOAMAPTSMN1; SMN2 | |
| SCHEMBL22797771 | 0.75 | SCN9A (0.77) | SCN9ARHOCRHOASMN1; SMN2MEN1 | |
| SCHEMBL22797791 | 0.74 | SCN9A (0.61) | SCN9ARHOCRHOA | |
| SCHEMBL20595173 | 0.74 | SCN9A (0.77) | SCN9ARHOCRHOASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3487839-B1 | AMIDE DERIVATIVES AS NAV1.7 AND NAV1.8 BLOCKERS | RAQUALIA PHARMA INC (JP) | 2020-12-23 | — | — | EP | disclosed |