Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2713871 | 0.79 | CYP1A2 (0.58) | LMNARECQLKMT2AMAPTKDM4E | |
| SCHEMBL2713671 | 0.76 | ADORA1 (0.51) | KMT2AMAPTKDM4EMEN1POLB | |
| SCHEMBL1180441 | 0.75 | MAPT (0.44) | LMNARECQLKMT2AMAPTKDM4E | |
| SCHEMBL2715069 | 0.75 | TSHR (0.55) | LMNARECQLKMT2AMAPTKDM4E | |
| SCHEMBL2714755 | 0.75 | ADORA1 (0.51) | LMNARECQLKMT2AMAPTALDH1A1 | |
| SCHEMBL22809648 | 0.74 | ADORA1 (0.53) | LMNAKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL18266209 | 0.74 | MAPT (0.39) | LMNARECQLKMT2AMAPTKDM4E | |
| SCHEMBL18266173 | 0.73 | MAPT (0.41) | LMNARECQLKMT2AMAPTKDM4E | |
| SCHEMBL18266634 | 0.73 | MAPT (0.44) | LMNARECQLKMT2AMAPTKDM4E | |
| SCHEMBL18266606 | 0.72 | MAPT (0.38) | LMNARECQLKMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3487839-B1 | AMIDE DERIVATIVES AS NAV1.7 AND NAV1.8 BLOCKERS | RAQUALIA PHARMA INC (JP) | 2020-12-23 | — | — | EP | disclosed |