Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | GCG | P01275 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6755097 | 0.87 | BACE1 (0.50) | BACE1MCHR1GCGDRD2ADRA1A | |
| SCHEMBL22809518 | 0.84 | BACE1 (0.54) | BACE1MCHR1GCGDRD2ADRA1A | |
| SCHEMBL28139619 | 0.84 | BACE1 (0.50) | BACE1MCHR1GCGDRD2ADRA1A | |
| SCHEMBL28070145 | 0.83 | BACE1 (0.59) | BACE1MCHR1GCGHRH3SCN9A | |
| SCHEMBL28350988 | 0.79 | BCHE (0.47) | BACE1MCHR1GCGSCN9AKDM4E | |
| SCHEMBL28350952 | 0.76 | BACE1 (0.45) | BACE1MCHR1GCGDRD2ADRA1A | |
| SCHEMBL22809481 | 0.75 | BACE1 (0.47) | BACE1SCN9A | |
| SCHEMBL7573712 | 0.74 | BACE1 (0.49) | BACE1MCHR1GCGHRH3CXCR3 | |
| SCHEMBL22545309 | 0.73 | MCHR1 (0.44) | BACE1MCHR1 | |
| SCHEMBL22809519 | 0.73 | BACE1 (0.41) | BACE1MCHR1GCGDRD2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3487839-B1 | AMIDE DERIVATIVES AS NAV1.7 AND NAV1.8 BLOCKERS | RAQUALIA PHARMA INC (JP) | 2020-12-23 | — | — | EP | disclosed |