Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 13/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | SCN7A | Q01118 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22809472 | 0.82 | BACE1 (0.54) | BACE1SCN9ASCN10APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL20595231 | 0.81 | BACE1 (0.53) | BACE1SCN9ASCN10APDE1APDE1B | |
| SCHEMBL28354796 | 0.80 | SCN9A (0.48) | SCN9ASCN10ASCN7AKCNH2SCN5A | |
| SCHEMBL28350726 | 0.75 | BACE1 (0.47) | BACE1SCN9ASCN10APDE1APDE1B | |
| SCHEMBL30465758 | 0.75 | MAPT (0.56) | — | |
| SCHEMBL22809595 | 0.75 | BACE1 (0.49) | BACE1SCN9A | |
| SCHEMBL22809583 | 0.74 | BACE1 (0.41) | BACE1SCN9ASCN10APDE1APDE1B | |
| SCHEMBL167871 | 0.74 | HTR1B (0.49) | KCNH2 | |
| SCHEMBL22809542 | 0.73 | RXFP1 (0.44) | RAF1KCNH2 | |
| SCHEMBL22809568 | 0.71 | L3MBTL4 (0.52) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3487839-B1 | AMIDE DERIVATIVES AS NAV1.7 AND NAV1.8 BLOCKERS | RAQUALIA PHARMA INC (JP) | 2020-12-23 | — | — | EP | disclosed |