Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | RIOK2 | Q9BVS4 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | GSK3B | P49841 | 6/20 | 0.44 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15627415 | 0.89 | TYK2 (0.52) | TYK2RIOK2MAPTGSK3BACVRL1 | |
| SCHEMBL27342084 | 0.87 | TYK2 (0.51) | TYK2RIOK2MAPTGSK3BACVRL1 | |
| SCHEMBL15358570 | 0.86 | TYK2 (0.50) | TYK2RIOK2MAPTGSK3BACVRL1 | |
| SCHEMBL21079055 | 0.86 | TYK2 (0.50) | TYK2RIOK2MAPTGSK3BACVRL1 | |
| Hydrochloric Acid SCHEMBL15350070 | 0.84 | TYK2 (0.49) | TYK2RIOK2MAPTGSK3BACVRL1 | |
| SCHEMBL25997633 | 0.83 | TYK2 (0.48) | TYK2RIOK2MAPTGSK3BACVRL1 | |
| SCHEMBL25714776 | 0.81 | RIOK2 (0.45) | TYK2RIOK2POLBNPC1RAB9A | |
| SCHEMBL23212152 | 0.80 | TYK2 (0.57) | TYK2RIOK2MAPTGSK3BACVRL1 | |
| SCHEMBL19728666 | 0.80 | TYK2 (0.53) | TYK2RIOK2MAPTGSK3BACVRL1 | |
| SCHEMBL19699534 | 0.80 | MAPT (0.59) | TYK2RIOK2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3487839-B1 | AMIDE DERIVATIVES AS NAV1.7 AND NAV1.8 BLOCKERS | RAQUALIA PHARMA INC (JP) | 2020-12-23 | — | — | EP | disclosed |