Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 7/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22809469 | 0.87 | HPGD (0.46) | HPGDRXFP1L3MBTL1ADORA2AADORA3 | |
| SCHEMBL30449743 | 0.77 | GSK3B (0.56) | HPGDRXFP1L3MBTL1ADORA2AADORA3 | |
| SCHEMBL29155745 | 0.77 | POLB (0.64) | HPGDRXFP1L3MBTL1ADORA2AADORA3 | |
| SCHEMBL2714790 | 0.76 | KDM4E (0.61) | HPGDRXFP1L3MBTL1ADORA2AADORA3 | |
| SCHEMBL11002946 | 0.73 | HPGD (0.45) | HPGDRXFP1L3MBTL1ADORA2AADORA3 | |
| SCHEMBL2715477 | 0.72 | JAK1 (0.47) | HPGDRXFP1L3MBTL1ADORA2AADORA3 | |
| SCHEMBL4550418 | 0.71 | ADORA1 (0.45) | HPGDRXFP1L3MBTL1ADORA2AADORA3 | |
| SCHEMBL22186405 | 0.71 | KDM4E (0.58) | HPGDRXFP1L3MBTL1ADORA2AADORA3 | |
| SCHEMBL4710625 | 0.70 | HPGD (0.47) | HPGDADORA2AADORA3ADORA1LMNA | |
| SCHEMBL4710626 | 0.70 | HPGD (0.47) | HPGDADORA2AADORA3ADORA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3487839-B1 | AMIDE DERIVATIVES AS NAV1.7 AND NAV1.8 BLOCKERS | RAQUALIA PHARMA INC (JP) | 2020-12-23 | — | — | EP | disclosed |