Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.51 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 3/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.38 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.38 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19563570 | 0.90 | SCN8A (0.51) | SCN8ASCN10ANFE2L2ARMAOB | |
| SCHEMBL22809756 | 0.90 | SCN8A (0.46) | SCN8ASCN10AMAPTNPSR1L3MBTL1 | |
| SCHEMBL30675650 | 0.83 | AR (0.47) | SCN8ASCN10ANFE2L2ARMAOB | |
| SCHEMBL19563650 | 0.83 | ALDH1A1 (0.44) | NFE2L2ARMAOBTSHRMAPT | |
| SCHEMBL1186123 | 0.81 | ALDH1A1 (0.50) | NFE2L2MAOBTSHRMAPTNPSR1 | |
| SCHEMBL18570724 | 0.81 | SCN8A (0.48) | SCN8ASCN10ATSHRMAPTL3MBTL1 | |
| SCHEMBL18570597 | 0.81 | SCN8A (0.48) | SCN8ASCN10ATSHRERN1ALDH1A1 | |
| SCHEMBL18570524 | 0.80 | SCN8A (0.51) | SCN8ASCN10ANFE2L2ARMAOB | |
| SCHEMBL19563576 | 0.80 | SCN8A (0.49) | SCN8ASCN10AMAPTNPSR1L3MBTL1 | |
| SCHEMBL18570715 | 0.77 | SCN8A (0.49) | SCN8ASCN10AMAPTNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |