Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | RAPGEF3 | O95398 | 3/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 10/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 9/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16729496 | 0.82 | NOTUM (0.36) | NOTUMMEN1KMT2AKDM4EGAA | |
| SCHEMBL17004899 | 0.82 | NOTUM (0.36) | NOTUMMEN1KMT2AKDM4EGAA | |
| SCHEMBL17004914 | 0.79 | ALDH1A1 (0.34) | NOTUMMEN1KMT2AMAPTPDK1 | |
| SCHEMBL16717135 | 0.79 | BRD4 (0.43) | NOTUMMEN1KMT2ABRD4CREBBP | |
| SCHEMBL16729497 | 0.79 | ALDH1A1 (0.34) | NOTUMMEN1KMT2AMAPTPDK1 | |
| SCHEMBL16717179 | 0.77 | KDM4E (0.41) | NOTUMMEN1KMT2AKDM4EGAA | |
| SCHEMBL17004951 | 0.77 | KDM4E (0.41) | NOTUMMEN1KMT2AKDM4EGAA | |
| SCHEMBL16717376 | 0.77 | BRD4 (0.35) | NOTUMBRD4CREBBP | |
| SCHEMBL16717155 | 0.76 | BRD4 (0.38) | MEN1KMT2ABRD4CREBBP | |
| SCHEMBL16717157 | 0.76 | BRD4 (0.38) | MEN1KMT2ABRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071203-B1 | TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS | FORMA THERAPEUTICS INC (US) | 2020-12-23 | — | — | EP | disclosed |