Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23126262 | 0.86 | CYP11B1 (0.40) | CYP11B1CYP11B2CHRNB2CHRNA4RET | |
| SCHEMBL20148645 | 0.85 | RET (0.42) | CYP11B1CYP11B2CHRNB2CHRNA4RET | |
| SCHEMBL20070424 | 0.85 | CYP11B1 (0.40) | CYP11B1CYP11B2CHRNB2CHRNA4RET | |
| SCHEMBL22812025 | 0.84 | ALDH1A1 (0.48) | CHRNB2CHRNA4CHRNA3CHRNA7RET | |
| SCHEMBL22031240 | 0.84 | RET (0.43) | CHRNB2CHRNA4RETTLR7 | |
| SCHEMBL21158871 | 0.82 | CYP11B1 (0.38) | CYP11B1CYP11B2CHRNB2CHRNA4RET | |
| SCHEMBL20070774 | 0.82 | RET (0.36) | RETTLR7 | |
| SCHEMBL22811902 | 0.82 | PREP (0.43) | RETKDM1AMAOAMAOBGRIN1 | |
| SCHEMBL22030585 | 0.81 | RET (0.46) | RETTLR7 | |
| SCHEMBL22031262 | 0.80 | RET (0.42) | RETTLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3753939-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | Array Biopharma Inc. (US) | 2020-12-23 | — | — | EP | disclosed |